Extensive subpial cortical demyelination is specific to multiple sclerosis
نویسندگان
چکیده
منابع مشابه
Subpial demyelination in the cerebral cortex of multiple sclerosis patients.
The extent and pattern of demyelination in the cerebral cortex was determined in 78 tissue blocks from the brains of 20 multiple sclerosis (MS) patients and 28 tissue blocks from 7 patients without neurological disease. Tissue blocks from 4 predetermined areas (cingulate gyrus, frontal, parietal, and temporal lobe) were studied, irrespective of macroscopically evident MS plaques. All tissue blo...
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Focal demyelinated plaques in white matter, which are the hallmark of multiple sclerosis pathology, only partially explain the patient's clinical deficits. We thus analysed global brain pathology in multiple sclerosis, focusing on the normal-appearing white matter (NAWM) and the cortex. Autopsy tissue from 52 multiple sclerosis patients (acute, relapsing-remitting, primary and secondary progres...
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Introduction. In patients with multiple sclerosis, whether cortical lesions and cortical atrophy reflect two different aspects of the same degenerative process, or have different biological substrates, has not yet been clarified. It is unclear when cortical disease is a consequence of white matter (WM) demyelination with secondary axonal damage leading to neuronal loss (secondary cortical patho...
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ژورنال
عنوان ژورنال: Brain Pathology
سال: 2020
ISSN: 1015-6305,1750-3639
DOI: 10.1111/bpa.12813